EA 4245 – University of Tours – Dendritic cells, immune modulation and grafts
- Director: Professor Christophe BARON
EA 4245 « CDG »
UFR de Médecine
10 boulevard Tonnellé -37032 Tours Cedex – France
- Téléphone : +33 (0) 2 47 36 61 46 (28)
- Télécopie : +33 (0) 2 47 36 61 47
- Site internet
RESEARCH AXIS
- Dendritic cells have a central role in the onset of the phenomena of rejection and tolerance induction, especially peripheral. The EA 4245 studies the role of dendritic cells in immune tolerance in organ transplant:
- Impact of the anti-CMV immune response on chronic graft outcome : genetic factors, clonal depletion
- Study of the biobank containing DNA from all patients transplanted in Tours since 1985, located in the laboratory (DC-2013-1780)
- Determination of the genetic risks of humoral rejection, first cause of kidney graft loss and correlation with other databases
- Development of induction strategies towards peripheral tolerance through cell therapy based on the development of pro-tolerogenic dendritic cells and regulator lymphocytes.
- Dendritic cell polarization during immune response
- Cardioprotection and cardiac graft survival optimization by modulating purine receptor signaling in dendritic cells.
UNIT STAFF
- Professors: 6
- Researchers – Lecturers: 10
- Technicians: 1
- PhD students: 6
- Master 2 students: 4
- Administrative staff: 2