EA 4245 – University of Tours – Dendritic cells, immune modulation and grafts

 

  • Director: Professor Christophe BARON

EA 4245 « CDG »
UFR de Médecine
10 boulevard Tonnellé -37032 Tours Cedex – France

  • Téléphone : +33 (0) 2 47 36 61 46 (28)
  • Télécopie : +33 (0) 2 47 36 61 47
  • Site internet

RESEARCH AXIS

  • Dendritic cells have a central role in the onset of the phenomena of rejection and tolerance induction, especially peripheral. The EA 4245 studies the role of dendritic cells in immune tolerance in organ transplant:
  • Impact of the anti-CMV immune response on chronic graft outcome : genetic factors, clonal depletion
  • Study of the biobank containing DNA from all patients transplanted in Tours since 1985, located in the laboratory (DC-2013-1780)
  • Determination of the genetic risks of humoral rejection, first cause of kidney graft loss and correlation with other databases
  • Development of induction strategies towards peripheral tolerance through cell therapy based on the development of pro-tolerogenic dendritic cells and regulator lymphocytes.
  • Dendritic cell polarization during immune response
  • Cardioprotection and cardiac graft survival optimization by modulating purine receptor signaling in dendritic cells.

UNIT STAFF

  • Professors: 6
  • Researchers – Lecturers: 10
  • Technicians: 1
  • PhD students: 6
  • Master 2 students: 4
  • Administrative staff: 2