UMR 1092 INSERM – University of Limoges – Anti-infective agents: Supports resistance and molecular therapeutic innovations

 

  • Director: Professor Marie-Cécile PLOY – Assistant Director: Professor Sophie ALAIN

Faculté de Médecine
2 rue du Docteur Marcland
87025 LIMOGES CEDEX – France

  • Telephone: +33 (0)5 55 43 59 74
  • Telecopie: +33 (0)5 55 05 67 22
  • Site internet

Unit guidelines concern the molecular mechanisms of resistance to antimicrobials, antibiotics and antivirals. The work focused on the study of the diversity of bacterial strains and virus resistant, to better understand the evolution of acquired resistance within microbial genomes and the kinetics of the emergence of resistance.

RESEARCH AXIS

Team 1: Role of integrons in multidrug resistance of bacteria to antibiotics
Leader: Professor Marie-Cécile PLOY

Team 2: Study of Cytomegalovirus (CMV) antiviral resistance
Leader: Professor Sophie ALAIN

The team 2 is integrated to the FHU SUPORT strategy. This team is studying the dynamics of the evolution of bacterial genomes due to antibiotic selection pressure. This work will help to better understand the evolution of the acquisition of resistance to antibiotics in bacteria, as well as environmental signals governing the acquisition.

THEMES IN RELATION TO ORGAN TRANSPLANTATION (TEAM 2)

  • Translational study on non-response factors to a curative anti-CMV treatment in kidney transplant recipients (ORPHAVIC national PHRC: ancillary study supported by CNR CMV)
  • Evaluation of the CMV infection risk in the R+ kidney transplant recipient following the analysis of cellular immunity by the QuantiFERON®-CMV test.
  • Study of the cellular diffusion and activation mechanisms of anti-CMV drugs (in collaboration with UMR 850)

UNIT STAFF

See the web site of the unit